College of Science

Weidong Zhou, PhD


PhD, Biochemistry, University of Illinois at Urbana-Champaign

Key Interests
Mass Spectrometry | Proteomics | Biomarker Discovery | Cancer Metabolism | Alzheimer’s Disease | Infectious Disease | Schizophrenia | Atrial Fibrillation

Research Focus

Our mass spectrometry lab is equipped with state-of-the-art mass spectrometers. My research is focused on biomarker discovery relevant to cancers and other diseases from serum, tissue and body fluids, using advanced liquid chromatography coupled nano-electrospray tandem mass spectrometry technique. I also collaborate with other researchers to develop effective mass spectrometry methods for protein identification and post-translational modification characterization.

Current Projects

■ Protein painting identifies therapeutic targets at protein-protein interfaces. The goal is to use protein painting to discover and validate therapeutic target hotspots for cell surface receptors, cancer cell signaling, oncogene/suppressor genes, and immunotherapy targets.

■ Microparticles for directing immune cell trafficking: The goal is to develop a nanoparticle technology based on a hydrogel incorporating affinity baits capable of controlled binding and release of chemokines, providing a predictable manipulation of the lymph node cellular composition.

■ Novel biomarkers of lung cancer to guide prevention and early diagnosis: The goal is to develop a quantitative MS assay for previously identified risk markers that are functionally involved in inflammation, genetic instability, autophagy, oxidative stress and innate immunity.

Select Publications

Z. M. Younossi et al., An exploratory study examining how nano-liquid chromatography-mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease. BMC Med. 16, 170 (2018).

C. DeMarino et al., Antiretroviral drugs alter the content of extracellular vesicles from HIV-1-infected cells. Sci Rep. 8, 7653 (2018).

B. D. Carey et al., Protein phosphatase 1α interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral replication through modulation of capsid phosphorylation. J Virol. 92(15), pii: e02068-17 (2018).


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