College of Science

M. Saleet Jafri, PhD

Professor,
Director,
Education

PhD, Biomathematical Sciences, Mount Sinai School of Medicine/City University of New York

Key Interests
Multiscale Systems Biology | Computational Biology | Bioinformatics | Cardiac Physiology | Immunology | Mitochondria | Cellular Signaling | Neuroscience | Algorithms | HPC

Research Focus

I apply computational analysis and modeling to answer fundamental and translational biomedical questions. My focus is understanding the molecular and cellular basis of normal and patho-physiology.

Current Projects

■ Computational modeling to address fundamental questions about agonist-induced calcium signaling and downstream targets

■ More recent scientific contributions are in the area of cardiac ventricular excitation-contraction coupling and mitochondrial energy metabolism and ionic homeostasis

■ Development of novel computational algorithms to address significant biological questions

■ Other research involves the development of new methods to understand genomic data and how they result in traits or disease

Select Publications

E. Munger et al., Application of machine learning to determine top predictors of non-calcified coronary burden in psoriasis: an observational cohort study. J Am Acad Dermatol, (in press).

H. Choi et al., Application of machine learning to determine top predictors of non-calcified coronary plaque burden in psoriasis. J Am Coll Cardiol 73(9 Supplement 1),1467 (2019).

M. D. McCoy et al., SNP2SIM: a modular workflow for standardizing molecular simulation and functional analysis of protein variants. BMC Bioinformatics 20, 171-178 (2019).

J. R. King et al., Ionotropic and metabotropic mechanisms of allosteric modulation of a7 nicotinic receptor intracellular calcium. Mol Pharmacol 93(6), 601-611 (2018).

 


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