Speaker: Dr. Koen Breyne – Harvard
Zoom Link: https://gmu.zoom.us/j/95055336656?pwd=Z3ZSUzArZk9vQy9ZcDA3NEtRZHBrUT09
Meeting ID: 950 5533 6656 Passcode: 145790
Speaker: Jade Jenkins
Online Location, Please click the event to view the link
Please join us at the following Zoom link shortly before noon. See you then!
Zoom password (if needed): 792171
AVACGIS Faculty Talk Series with Cortney Hughes Rinker
Speaker: Roshan Bastani, PhD
Director of UCLA Kaiser Permanente Center for Health Equity & UCLA Center for Prevention Research
Professor Health Policy and Management
UCLA Fielding School of Public Health
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Carmen Canavier, Ph.D.
Mullins Professor and Interim Head,
Department of Cell Biology and Anatomy
Louisiana State University Health Sciences Center
New Orleans, LA
Abstract: Area CA1 of the hippocampus is thought to play a key role in learning and memory, specifically episodic memories, sequential order and trace conditioning. In behaving rodents, CA1 pyramidal neurons receive spatially-tuned depolarizing synaptic input while traversing a specific location within an environment called its place. Midbrain dopamine neurons participate in reinforcement learning, and bursts of action potentials riding a depolarizing wave of synaptic input signal rewards and reward expectation. Interestingly, slice electrophysiology in vitro shows that both types of cells exhibit a pronounced reduction in firing rate (adaptation) and even cessation of firing during sustained depolarization. In response to a temporally symmetric current ramp, the firing rate adapts so that the neuron fires substantially less on the down ramp compared to the up ramp. Such adaptation is likely to affect the dependence of the firing rate of CA1 neurons on position within the place field. Our experiments in vitro show that adaptation in these neurons in response to a symmetric current ramp is more pronounced in the apical dendrite than in the soma. Our simulations of a biophysically and morphologically detailed pyramidal neuron were calibrated using data from the literature that shows slow inactivation of the sodium current increases with distance along the apical trunk. A five state Markov model of NaV1.6 suggests that slow inactivation of this channel is responsible for this adaptation, consistent with our experimental data showing that the SK, M and ERG potassium channels are not major contributors to this adaptation. Our experimental data shows that the cholinergic agonist CCh reverses the adaptation and produces acceleration of the firing rate on the down ramp instead. Both FFA and a specific TRPM blocker largely occlude the effects of CCh. We implemented a detailed model of calcium handling including calcium-induced calcium release co-localized with the TRPM channel, and simulate the effect of CCh primarily via an increase in IP3 in order to capture the acceleration on the down ramp. We also present recent data showing the differential contribution of slow inactivation in two subpopulations of midbrain dopamine neurons accounts for their different dynamic range, as assessed by their responses to similar depolarizing ramps. These results suggest slow inactivation of the sodium channel is a general mechanism for adaptation.
This virtual event will be held via a unique space created in gather.town. You can learn more about this platform here: https://gather.town. Posters will be on display beginning April 16 and remain available until the end of Spring semester. Student presenters will be expected to be present to talk with judges during the two hour event on April 21.
The College of Science and STEM Accelerator are pleased to announce the Call for Presentations for the 10th Annual Undergraduate Research Colloquium. The purpose of this event is to showcase the variety of undergraduate research projects in the College to other students and faculty.
Speaker: Ilkay Oksuz, Ph.D.
Assistant Professor, Computer Engineering Department, Istanbul Technical University
Istanbul, Turkey
Speaker: Yaa Akosa Antwi, Ph.D., Assistant Professor, Carey School of Business, Johns Hopkins University presents, “Does Physician Reimbursement Affect Treatment? Evidence from Restricting Balance Billing in California”
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Contact: Department of Health Administration and Policy, visit here to send message
Panelists: Delegate Charniele Herring, Majority Leader, Virginia House of Delegates
Marc Spear, Chief Financial Officer, Camaraderie Holdings
A panel discussion on Marijuana Legalization in Virginia with DelegateCharniele Herring, Majority Leader of the Virginia House of Delegates
Marc Spear, CFO of Camaraderie Holdings.
This is a free event open to the Mason community and public.
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Speaker: Fatah Kashanchi, Ph.D.
Professor, Department of Systems Biology,
George Mason University