Calendar

Dr. Natasha Cabrera

Wednesday, November 4, 2020 12:00 PM to 1:00 PM
Online Location, Please click here to view the link

Please join us at the following Zoom link shortly before noon. See you then!

Zoom password (if needed): gmupsych

Speaker: Allan Doctor, M.D.

Abstract: There is need for an artificial oxygen (O₂) carrier for use when stored blood is unavailable or undesirable. To date, efforts to develop hemoglobin (Hb) based oxygen carriers (HBOCs) have failed, because of design flaws which do not preserve physiologic interactions of Hb with: O₂ (they capture O₂ in lungs, but do not release O₂ effectively to tissue) and nitric oxide (NO) (they trap NO, causing vasoconstriction). EM design surmounts these weaknesses by: encapsulating Hb, controlling O₂ capture/release with a novel 2,3-DPG shuttle and attenuating NO uptake through shell properties. We will review the bio-mimetic design strategy for EM as well as results of lead protype characterization regarding (1) structure (2) biocompatibility, (3) O₂ affinity, (3) rheology, (4) NO consumption & vasoactivity, (5) pharmacokinetics, and (6) in vivo efficacy. The EM prototype has passed rigorous initial ex vivo and in vivo “proof of concept” testing and bench testing, which suggests this design surmounts prior challenges (by HBOCs) in emulating normal RBC physiologic interactions with O₂ and NO. In models of major bleeding/anemia, EM reconstitutes normal hemodynamics and O₂ delivery, observed at the system, tissue, and cellular level. EM potential for extended ambient dry storage has significant implications for portability and use. Next steps include formulation scaling, detailed study of pharmacokinetics, biodistribution and safety, as well as evaluation in large animal models of hemorrhagic shock.

Biography: Allan Doctor, MD is a Professor of Pediatrics at the University of Maryland School of Medicine, where he directs the Center for Blood Oxygen Transport and Hemostasis. He is a Pediatric Intensivist and previously led Pediatric Critical Care at Washington University and St Louis Children’s Hospital for 10 years, stepping down and then transitioning to UMB to focus on a rapidly expanding research program and on development of a novel bio-synthetic artificial red cell. His laboratory studies the role of red blood cell-based signaling in the control of regional blood flow, related pathophysiology arising from acquired red cell injuries, blood substitute design, and on translational transfusion medicine in critical illness.

Join Zoom Meeting—https://gmu.zoom.us/j/92554249038?pwd=V2p1ZUdqM1Y2RnBCcWhDU0V0T2FZZz09

Meeting ID: 925 5424 9038   Passcode: 640851

Presenter: Dr. Fatah Kashanchi, Professor, Virology Director of the Laboratory of Molecular Virology, GMU

As part of the effort to further strengthen our microbiology program and in consultation with several faculty, I have initiated a virtual Microbiology Journal Club with an emphasis on COVID-19 (MJC_COVID-19).  Given the immense worldwide effect of the pandemic, it is also a timely endeavor. It will be held once a month during the fall and spring semesters. The meetings will be on Fridays at 11 am. They are fully open to the Mason community, and I hope that everyone can join in and participate (please see below for how to join by Zoom). 

While the emphasis will be on COVID-19, presenters are certainly welcome to discuss published articles on other topics as well if they wish to do so. Faculty members, postdoctoral fellows, and PhD students who have advanced to candidacy, are welcome to present. Please let me know if either you wish to present yourself or have a postdoctoral fellow or eligible PhD student in your lab who wishes to present, and I will include them in the schedule.

Join Zoom Meeting
https://us02web.zoom.us/j/89207023729?pwd=NGdmNmNOSGxhYjF5R09rWWtaM1VXdz09

Meeting ID: 892 0702 3729
Passcode: 0wnMbD

Panelists:
Katherine H. Campbell MD, MPH
Assistant Professor, Yale Maternal Fetal Medicine
Medical Director, Yale-New Haven Hospital Labor & Birth and Maternal Special Care Units
Department of Obstetrics, Gynecology, and Reproductive Sciences
Yale School of Medicine

Rosemary D. Higgins, MD
Associate Dean for Research,  Interim Chair, Rehabilitation Sciences
Professor, Department of Global and Community Health, CHHS, GMU

Since the start of the pandemic, knowledge has evolved about the implications of COVID-19 on the health of mothers and infants, however many questions still remain. Dr. Katherine Campbell and Dr. Rosemary Higgins will share findings on possible short and long-term implications for obstetrics and maternal health. Current guidance for pregnant women and their infants will be covered in this session.

Please  Register Here

Speaker:  Ellen Montz, PhD
Chief Deputy & Chief Health Economist, Virginia’s Department of Medical Assistance Services (DMAS)

What does the election outcome mean for state health policy development? Dr. Montz, Chief Deputy of the department that oversees Virginia’s Medicaid program, will share her views.
RSVP Here

The morning is organized into three themes, each of which is followed by a panel discussion :
Theme 1: Imaging and Image Guided Surgery
Theme 2: Cellular and Molecular Therapeutics and Biomanufacturin
Theme 3: Artificial Intelligence, Machine Learning and Digital Health

Please scroll to the bottom of this email for the Zoom link and instructions to attend virtually.

Mason Bioengineering Alliance Research Symposium
Monday, November 16, 2020
9:00 am – 12:15 pm

Join Zoom Meeting

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Meeting ID: 958 4279 7665
Passcode: 098410
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Meeting ID: 958 4279 7665   Passcode: 098410

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Join by SIP   95842797665@zoomcrc.com

Hosted by the Arlington Partnership for Affordable Housing

Details to follow. 

Speaker: Dr. Fantasy Lozada

Please join us at the following Zoom link shortly before noon. See you then!
Zoom password (if needed): gmupsych

Speaker: Lance Liotta, MD, PhD, Mason College of Science University Professor

BIO: Since 2005 Dr. Liotta has served as Co-Director and Co-Founder of the Center for Applied Proteomics and Molecular Medicine (CAPMM) at George Mason University. Prior to this appointment, Dr. Liotta served as Chief of the Laboratory of Pathology, NCI, Deputy Director of NIH, Co-Director of the NCI/FDA Clinical Proteomics Program, and Director of the Anatomic Pathology Residency Program.  Dr. Liotta has more than 100 issued or allowed patents and more than 690 publications. He is an ISI highly cited investigator and the recipient of numerous awards for biomedical research including the 2015 Outstanding Virginia Faculty Award (SCHEV), the Flemming Award for Cancer Research, the Warner-Lambert Parke Davis Award, and the Surgeon General’s Medallion. He is Board Certified in Anatomic Pathology and is Medical Director of the GMU CAP/CLIA certified clinical proteomics Lab.

Hear about the latest findings surrounding hot topics in science and medicine that affect our everyday lives and the decisions that we make! Bring your family and friends for a free, casual, interactive science discussion. Learn from the experts and speak with them.

Location: Face to face sessions will be held at the Mason Science and Tech Campus at Manassas, VA. Remote sessions will be held by preregistering on Mason Zoom. Find instructions on how to join us under each session title.

Evening Schedule:

For face-to-face sessions:

6:30 PM: Seating begins. Individual light meal and beverages served.
7:00-7:45 PM: Scientific discussion
7:45-8:15 PM: Ask the presenters! Questions from the audience
8:15-8:45 PM: Meet the scientist and networking reception (Socially Distanced)
9:00 PM  Session closes

For remote sessions:

6:45 PM: Logon
7:00-7:45 PM: Scientific discussion
7:45-8:15 PM: Q&A from audience
8:15-8:45 PM: Meet the scientist and networking reception
9:00 PM  Session closes

Presenter: Dr. Emanuel F. Petricoin, Co-Director of CAPMM, SSB, GMU. 

As part of the effort to further strengthen our microbiology program and in consultation with several faculty, I have initiated a virtual Microbiology Journal Club with an emphasis on COVID-19 (MJC_COVID-19).  Given the immense worldwide effect of the pandemic, it is also a timely endeavor. It will be held once a month during the fall and spring semesters. The meetings will be on Fridays at 11 am. They are fully open to the Mason community, and I hope that everyone can join in and participate (please see below for how to join by Zoom).

While the emphasis will be on COVID-19, presenters are certainly welcome to discuss published articles on other topics as well if they wish to do so. Faculty members, postdoctoral fellows, and PhD students who have advanced to candidacy, are welcome to present. Please let me know if either you wish to present yourself or have a postdoctoral fellow or eligible PhD student in your lab who wishes to present, and I will include them in the schedule.

Join Zoom Meeting
https://us02web.zoom.us/j/89207023729?pwd=NGdmNmNOSGxhYjF5R09rWWtaM1VXdz09

Meeting ID: 892 0702 3729
Passcode: 0wnMbD