Speaker: Andreas Linninger, Ph.D. (Professor, Department of Bioengineering, University of Illinois at Chicago, IL)
Topic: Cerebral Blood Flow and Solute Transport in the Central Nervous System
Video conferencing is available.
Abstract: The cerebral circulation ensures that systemic blood supplies oxygen and nutrients and removes waste products from the delicate brain tissues. Blood flow pattern in the normal as well as pathological states have been predicted successfully with fluid mechanical principles. For example, much about what is now known about rupture risks in cerebral aneurysm we owe to pioneering research by Cebral and coworkers.
The remarkable achievements of fluid mechanics in vascular diseases have prompted researchers to deploy computer simulations as a tool of scientific inquiry into experimentally elusive mechanisms regarding the spatio-temporal coordination of blood flow as well as substrate and momentum transfer between the entire cerebral circulation, cerebrospinal fluid (CSF) and brain tissues. To address open questions about key metabolic functions of the brain, we harness predictive mathematical models informed by three-dimensional dynamic imaging data. This lecture will survey current knowledge of cerebral circulation and CSF dynamics including natural CSF flow patterns and mixing phenomena of solute in CSF. We present computational techniques to realize rigorous three-dimensional, dynamic blood flow simulations for entire arterial trees in specific human subjects. Our computations also demonstrate the practicality of simulating blood flow for large portions of the mouse brain with existing computer resources. The efficient simulation of blood flow throughout the entire MCA territory is a promising milestone towards the final aim of predicting blood flow patterns for the entire brain.
Dr. Andreas Linninger is a professor of bioengineering and neurosurgery (courtesy) at the University of Illinois at Chicago. He held research positions at the Vienna University of Technology, The University of California at Berkeley and The Massachusetts Institute of Technology. His research interests are in cerebral blood flow and metabolism, drug delivery to the central nervous system and brain pathologies such as hydrocephalus.